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Article

Predictive Utility of a Validated Polygenic Risk Score for Long-Term Risk of Coronary Heart Disease in Young and Middle-Aged Adults.

Circulation - 23 Aug 2022

Khan Sadiya S, Page Courtney, Wojdyla Daniel M, Schwartz Yosef Y, Greenland Philip, Pencina Michael J

Abstract excerpt

BACKGROUND: Understanding the predictive utility of previously derived polygenic risk scores (PRSs) for long-term risk of coronary heart disease (CHD) and its additive value beyond traditional risk factors can inform prevention strategies. METHODS: Data from adults 20 to 59 years of age who were free of CHD from the FOS (Framingham Offspring Study) and the ARIC (Atherosclerosis Risk in Communities) study were...

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Identifiers

PMID: 35880530
DOI: 10.1161/CIRCULATIONAHA.121.058426
PMCID: PMC9398962

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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