Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genomic prediction of coronary heart disease.

European heart journal - 14 Nov 2016

Abraham Gad, Havulinna Aki S, Bhalala Oneil G, Byars Sean G, De Livera Alysha M, Yetukuri Laxman, Tikkanen Emmi, Perola Markus, Schunkert Heribert, Sijbrands Eric J, Palotie Aarno, Samani Nilesh J, Salomaa Veikko, Ripatti Samuli, Inouye Michael

Abstract excerpt

AIMS: Genetics plays an important role in coronary heart disease (CHD) but the clinical utility of genomic risk scores (GRSs) relative to clinical risk scores, such as the Framingham Risk Score (FRS), is unclear. Our aim was to construct and externally validate a CHD GRS, in terms of lifetime CHD risk and relative to traditional clinical risk scores. METHODS AND RESULTS: We generated a GRS of 49 310 SNPs based on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Coronary Disease
Share to Genomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heart Diseases

Share to Polymorphism, Single Nucleotide

Share to Risk Assessment

Share to Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 27655226
DOI: 10.1093/eurheartj/ehw450
PMCID: PMC5146693

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genomic prediction of coronary heart disease.PMID 27655226Read ↗

Genomic prediction of coronary heart diseaseSemantic proximity Read ↗

Incremental Value of Polygenic Risk Scores in Primary Prevention of Coronary Heart Disease: A Review.Semantic proximity Read ↗

Genomic risk prediction of coronary artery disease in nearly 500,000 adults: implications for early screening and primary preventionSemantic proximity Read ↗

Meta-Prediction of Coronary Artery Disease RiskSemantic proximity Read ↗

Predictive Utility of a Validated Polygenic Risk Score for Long-Term Risk of Coronary Heart Disease in Young and Middle-Aged Adults.Semantic proximity Read ↗

How close are we to implementing a genetic risk score for coronary heart disease?Semantic proximity Read ↗

A polygenic risk score for coronary heart disease performs well in individuals aged 70 years and olderSemantic proximity Read ↗

Incremental predictive value of 152 single nucleotide polymorphisms in the 10-year risk prediction of incident coronary heart disease: the Rotterdam Study.Semantic proximity Read ↗

Coronary heart disease risk prediction in the era of genome-wide association studies: current status and what the future holds.Semantic proximity Read ↗

A genetic risk score is associated with incident cardiovascular disease and coronary artery calcium: the Framingham Heart Study.Semantic proximity Read ↗

Risk prediction by genetic risk scores for coronary heart disease is independent of self-reported family history.Semantic proximity Read ↗

Genetic markers enhance coronary risk prediction in men: the MORGAM prospective cohorts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.