Article
Detection of Allele-Specific 3D Chromatin Interactions Using High-Resolution In-Nucleus 4C-seq.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2022
Miranda Mélanie, Noordermeer Daan, Moindrot Benoit
Abstract excerpt
Chromosome conformation capture techniques are a set of methods used to determine 3D genome organization through the capture and identification of physical contacts between pairs of genomic loci. Among them, 4C-seq (circular chromosome conformation capture coupled to high-throughput sequencing) allows for the identification and quantification of the sequences interacting with a preselected locus of interest....
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