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Article

Impact of Intrahost NS5 Nucleotide Variations on Dengue Virus Replication

5 Jul 2022

Abstract excerpt

Due to the nature of RNA viruses, their high mutation rates produce a population of closely related but genetically diverse viruses, termed quasispecies. To determine the role of quasispecies in DENV disease severity, 22 isolates (10 from mild cases, 12 from fatal cases) were obtained, amplified, and sequenced with Next Generation Sequencing using the Illumina MiSeq platform. Using variation calling, unique...

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PMID: 35865937
DOI: 10.3389/fmicb.2022.894200

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