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In Silico Analysis of Dengue Virus Serotype 2 Mutations Detected at the Intrahost Level in Patients with Different Clinical Outcomes.

Microbiology spectrum - 31 Oct 2021

Torres Maria Celeste, Martins Karl Ana Luiza, Müller Pereira da Silva Matheus, Dardenne Laurent Emmanuel, Bispo de Filippis Ana Maria

Abstract excerpt

Intrahost genetic diversity is thought to facilitate arbovirus adaptation to changing environments and hosts, and it may also be linked to viral pathogenesis. Intending to shed light on the viral determinants for severe dengue pathogenesis, we previously analyzed the DENV-2 intrahost genetic diversity in 68 patients clinically classified as dengue fever (n = 31), dengue with warning signs (n = 19), and severe...

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Identifiers

PMID: 34468189
DOI: 10.1128/Spectrum.00256-21
PMCID: PMC8557815

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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