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A non-structural protein 1 substitution of dengue virus enhances viral replication by interfering with the antiviral signaling pathway

20 Feb 2025

Abstract excerpt

BACKGROUND: The largest dengue virus 2 (DENV2) outbreak occurred in Taiwan in 2015, resulting in many fatalities. We therefore aim to identify crucial genetic variations which determine the virulence of the 2015 Taiwan outbreak strains. METHODS: We compared the 2015 Taiwan DENV2 sequences to the pre-2015 sequences. Reverse genetics (rg) viruses with substitutions were produced and the viral growth kinetics were...

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PMID: 39972477
DOI: 10.1186/s12929-024-01116-4

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