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Virulence difference of five type I dengue viruses and the intrinsic molecular mechanism

4 Mar 2019

Abstract excerpt

Dengue virus (DENV) is the most important vector-borne virus globally.The safe and effective vaccines are still under development and there are no antiviral drugs for DENV induced diseases.In this study, we obtained five DENV1 isolates (DENV1 A to E) from the outbreak of dengue fever in 2014 of Guangzhou, China, and analyzed their replication efficiency and virulence in vitro and in vivo.The results suggested...

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PMID: 30830907
DOI: 10.1371/journal.pntd.0007202

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