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Article

Envelope domain III E324, E351, and E380 mutations lever adaptive evolution of DENV-1 genotype I.

Journal of virology - 22 Oct 2024

Jiang Tao, Huang Chenxiao, Ruan Qianqian, Huang Xiaorong, Liang Chumin, Chen Zhiqiang, Yu Xi, Peng Yihao, Liu Zheng, Cheng Gong, Dai Jianfeng, Sun Jiufeng

Abstract excerpt

Dengue virus (DENV) gains genetic mutations during continuous transmission and evolution, making the virus more adaptive and virulent. The clade of DENV-1 genotype I has expanded and become the predominant genotype in Asia and the Pacific areas, but the underlying mechanisms are unclear. A combined analysis of nonsynonymous mutations in domain III of the envelope protein and their biological effects on virus...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39230303
DOI: 10.1128/jvi.01183-24
PMCID: PMC11495034

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