Dengue virus-1 NS5 genetic variant associated with a severe clinical infection: Possible reduction of the innate immune response by inhibition of interferon type 1 and the Janus kinase-signal transducer and activator of transcription signaling pathway.

doi:10.3892/ijmm.2018.3395

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Article

Dengue virus-1 NS5 genetic variant associated with a severe clinical infection: Possible reduction of the innate immune response by inhibition of interferon type 1 and the Janus kinase-signal transducer and activator of transcription signaling pathway.

International journal of molecular medicine - 1 Apr 2018

Delgado-Enciso Iván, López-Lemus Uriel A, Valcarcel-Gamiño Jose A, Rodriguez-Sanchez Iram P, Valle-Reyes Salvador, Martinez-Fierro Margarita L, Melnikov Valery, Guzmán-Esquivel José, Vaca-Paniagua Felipe, Valdez-Velazquez Laura L, Baltazar-Rodriguez Luz M, Soriano-Hernandez Alejandro D, Paz-Michel Brenda, Espinoza-Gómez Francisco

Abstract excerpt

Dengue virus (DENV) is currently considered as one of the most important mosquito-borne viral pathogens affecting humans. Genetic variations in viruses are likely to be a condition for more effective evasion of the immune system and resulting in severe clinical consequences. The DENV‑1 NS5 gene was sequenced to establish whether during an epidemic burst there were genetic variations of the virus and whether any...

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PMID: 29344662
DOI: 10.3892/ijmm.2018.3395

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