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Article

Transcutaneous Vagus Nerve Stimulation Ameliorates the Phenotype of Heart Failure With Preserved Ejection Fraction Through Its Anti-Inflammatory Effects.

Circulation. Heart failure - 1 Aug 2022

Elkholey Khaled, Niewiadomska Monika, Morris Lynsie, Whyte Seabrook, Houser Jeremy, Humphrey Mary Beth, Stavrakis Stavros

Abstract excerpt

BACKGROUND: A systemic proinflammatory state plays a central role in the development of heart failure with preserved ejection fraction (HFpEF). Low-level transcutaneous vagus nerve stimulation (LLTS) suppresses inflammation in animals and humans, mediated by an α7nAchR (alpha7 nicotinic acetylcholine receptor)-dependent pathway. We examined the effects of LLTS on cardiac function, inflammation, and fibrosis in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35862007
DOI: 10.1161/CIRCHEARTFAILURE.122.009288
PMCID: PMC9388556

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