Article
Phenotype-Specific Treatment of Heart Failure With Preserved Ejection Fraction: A Multiorgan Roadmap.
Circulation - 5 Jul 2016
Shah Sanjiv J, Kitzman Dalane W, Borlaug Barry A, van Heerebeek Loek, Zile Michael R, Kass David A, Paulus Walter J
Abstract excerpt
Heart failure (HF) with preserved ejection fraction (EF; HFpEF) accounts for 50% of HF cases, and its prevalence relative to HF with reduced EF continues to rise. In contrast to HF with reduced EF, large trials testing neurohumoral inhibition in HFpEF failed to reach a positive outcome. This failure was recently attributed to distinct systemic and myocardial signaling in HFpEF and to diversity of HFpEF...
Topics
- Combined Modality Therapy
- Comorbidity
- Coronary Disease
- Endothelium, Vascular
- Female
- Heart Failure
- Humans
- Hypertension
- Hypertension, Pulmonary
- Inflammation
- Kidney Diseases