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Article

Vagus nerve stimulation optimized cardiomyocyte phenotype, sarcomere organization and energy metabolism in infarcted heart through FoxO3A-VEGF signaling.

Cell death & disease - 12 Nov 2020

Luo Bin, Wu Yan, Liu Shu-Lin, Li Xing-Yuan, Zhu Hong-Rui, Zhang Lei, Zheng Fei, Liu Xiao-Yao, Guo Ling-Yun, Wang Lu, Song Hong-Xian, Lv Yan-Xia, Cheng Zhong-Shan, Chen Shi-You, Wang Jia-Ning, Tang Jun-Ming

Abstract excerpt

Vagus nerve stimulation (VNS) restores autonomic balance, suppresses inflammation action and minimizes cardiomyocyte injury. However, little knowledge is known about the VNS' role in cardiomyocyte phenotype, sarcomere organization, and energy metabolism of infarcted hearts. VNS in vivo and acetylcholine (ACh) in vitro optimized the levels of α/β-MHC and α-Actinin positive sarcomere organization in cardiomyocytes...

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Identifiers

PMID: 33184264
DOI: 10.1038/s41419-020-03142-0
PMCID: PMC7665220

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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