Article

Ultrasound neuromodulation of an anti-inflammatory pathway at the spleen produces sustained improvement of experimental pulmonary hypertension

2023-03-28

Abstract excerpt

<h4>Background</h4> Inflammation is pathogenically implicated in pulmonary arterial hypertension (PAH); however, it has not been adequately targeted therapeutically. We investigated whether neuromodulation of an anti-inflammatory neuroimmune pathway involving the splenic nerve using noninvasive, focused ultrasound stimulation of the spleen (sFUS) can improve experimental pulmonary hypertension (PH). <h4>Methods</...

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Literature Corpus work: c8df4429-aedc-5b59-9526-de1a82bf28ea
DOI: 10.1101/2023.03.28.534567

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