Article

β₃-Adrenergic Signaling in Heart Failure: A Stage-Dependent Double-Edged Sword

2025-12-22

Abstract excerpt

Heart failure (HF) is a heterogeneous clinical syndrome in which abnormalities of myocardial relaxation, contractile performance, and neurohormonal activation contribute variably across disease phenotypes and stages. While advanced heart failure with reduced ejection fraction (HFrEF) is dominated by impaired systolic function and low cardiac output, heart failure with preserved ejection fraction (HFpEF) and earlie...

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Literature Corpus work: a4646476-d5f6-51af-9d8a-dc02e87ca4d0
DOI: 10.20944/preprints202512.1978.v1

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