Article

Integrated analysis reveals neuro-immune pathway in the central nervous system that supports SGLT2i’s protective effects in treatment of cardiac remodeling

2025-10-03

Abstract excerpt

<h4>Background</h4> Growing evidence are showing beneficial effects of sodium glucose transport protein 2 inhibitors (SGLT2i) in treatment of heart failure, but underlying neurogenic mechanism remains unclear. In this study the effect of empagliflozin (EM) on sympatho-excitation and potential neurogenic mechanism for EM’s therapeutic effects on cardiac remodeling were studied. <h4>Methods</h4> Deoxycorticosteron...

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Literature Corpus work: 51a7fff2-e0e0-5932-91bf-6e6aa434b8b1
DOI: 10.1101/2025.10.02.674829

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