Article

Repurposing Nintedanib for Pathological Cardiac Remodeling and Dysfunction

2020-12-22

Abstract excerpt

<h4>Background</h4> Heart Failure (HF) is the leading cause of death worldwide. Myocardial fibrosis, one of the clinical manifestations implicated in almost every form of heart disease, contributes significantly to HF development. However, there is no approved drug specifically designed to target cardiac fibrosis. Nintedanib (NTB) is an FDA approved tyrosine kinase inhibitor for idiopathic pulmonary fibrosis (IPF...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fa4798fb-fa29-5739-a5a3-67ecb3ee92d6
DOI: 10.1101/2020.12.21.423817

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Repurposing Nintedanib for Pathological Cardiac Remodeling and DysfunctionDOI 10.1101/2020.12.21.423817Read

Cardiac fibrosis: Pathobiology and therapeutic targetsSemantic proximity Read

The cardiac enigma: current conundrums in heart failure researchSemantic proximity Read

Therapeutic potential of Relaxin-2 in Heart Failure with preserved Ejection Fraction (HFpEF)Semantic proximity Read

Revolutionizing cardiac fibrosis treatment: the potential of personalized CAR T-cell therapySemantic proximity Read

Fendrr involves in the pathogenesis of cardiac fibrosis via regulating miR-106b/SMAD3 axisSemantic proximity Read

Small molecule-induced ERBB4 activation to treat heart failureSemantic proximity Read

Baricitinib improves the efficacy of nintedanib for the treatment of idiopathic pulmonary fibrosisSemantic proximity Read

Combining three independent pathological stressors induces a heart failure with preserved ejection fraction phenotype.Semantic proximity Read

AI-based Predictive Signaling Pathway Profiling in Cardiac Fibrosis Suggests a Novel Combinatorial Treatment StrategySemantic proximity Read

A noble TGFβ biogenesis inhibitor exhibits both potent anti-fibrotic and anti-inflammatory capabilitiesSemantic proximity Read

Cardiac reanimation: targeting cardiomyocyte death by BNIP3 and NIX/BNIP3LSemantic proximity Read

Buyanghuanwu Decoction alleviated pressure overload induced cardiac remodeling by suppressing Tgf-β/Smads and MAPKs signaling activated fibrosis.Semantic proximity Read