Phytosterol Accumulation Results in Ventricular Arrhythmia, Impaired Cardiac Function and Death

Abstract excerpt

Heart failure (HF) and cardiac arrhythmias share overlapping pathological mechanisms that act cooperatively to accelerate disease pathogenesis. Cardiac fibrosis is associated with both pathological conditions. Our previous work identified a link between phytosterol accumulation and cardiac injury in a mouse model of phytosterolemia, a rare disorder characterized by elevated circulating phytosterols and increased c...

Topics

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• 3-Hydroxyacyl CoA Dehydrogenases
• Arrhythmias, Cardiac
• Cardiomyopathies
• Heart Rate
• Lipid Metabolism, Inborn Errors
• Mice, Inbred C57BL
• Myocytes, Cardiac
• Oxidative Stress

Identifiers and source

Literature Corpus work

959b0c6d-4eda-571c-9e39-17b8bd792942

DOI

10.21203/rs.3.rs-474251/v1