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Article

Genetic and environmental variation impact transferability of polygenic risk scores.

Cell reports. Medicine - 19 Jul 2022

Araújo Daniel S, Wheeler Heather E

Abstract excerpt

Even when polygenic risk scores (PRSs) are trained in African ancestral populations, Kamiza and colleagues showed that genetic and environmental variation within sub-Saharan African populations impacts prediction performance, highlighting the challenges of clinical implementation of PRSs for risk assessment.

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Identifiers

PMID: 35858592
DOI: 10.1016/j.xcrm.2022.100687
PMCID: PMC9381406

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