Article

Polygenic prediction of lipid traits in sub-Saharan Africans

2021-08-24

Abstract excerpt

<title>Abstract</title> <p>Polygenic risk scores (PRS) can enhance risk stratification and are useful for precision medicine interventions. Here we show that African American Genome-wide Association Study (GWAS) derived PRS enhance prediction of lipid traits in Sub-Saharan Africans. Our PRS prediction varied greatly between South African Zulus (LDL-C, R2 = 8.49%) and Ugandans (LDL-C, R2= 0.043%), potentially attr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2c27986b-a44d-5bcf-9e68-4895a0a8a144
DOI: 10.21203/rs.3.rs-824992/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Polygenic prediction of lipid traits in sub-Saharan AfricansDOI 10.21203/rs.3.rs-824992/v1Read

Polygenic Risk Score in African populations: progress and challengesSemantic proximity Read

Polygenic risk scores for disease risk prediction in Africa: current challenges and future directions.Semantic proximity Read

Ancestry-aligned polygenic scores combined with conventional risk factors improve prediction of cardiometabolic outcomes in African populations.Semantic proximity Read

Genetic Risk Scores for Cardiometabolic Traits in Sub-Saharan African PopulationsSemantic proximity Read

Genetic risk scores for cardiometabolic traits in sub-Saharan African populations.Semantic proximity Read

Bridging traditional risk factors and genetic insights: A review on polygenic risk scores in cardiovascular diseasesSemantic proximity Read

Low and differential polygenic score generalizability among African populations due largely to genetic diversity.Semantic proximity Read

Polygenic Prediction of Type 2 Diabetes in Africa.Semantic proximity Read

Associations of cardiometabolic polygenic risk scores with cardiovascular disease in African AmericansSemantic proximity Read

Validity of European-centric derived cardiometabolic polygenic risk scores in multi-ancestry populationsSemantic proximity Read

The evolution of genetic-based risk scores for lipids and cardiovascular diseaseSemantic proximity Read

Genetic risk prediction in complex disease.Semantic proximity Read