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Article

Low and differential polygenic score generalizability among African populations due largely to genetic diversity.

HGG advances - 13 Apr 2023

Majara Lerato, Kalungi Allan, Koen Nastassja, Tsuo Kristin, Wang Ying, Gupta Rahul, Nkambule Lethukuthula L, Zar Heather, Stein Dan J, Kinyanda Eugene, Atkinson Elizabeth G, Martin Alicia R

Abstract excerpt

African populations are vastly underrepresented in genetic studies but have the most genetic variation and face wide-ranging environmental exposures globally. Because systematic evaluations of genetic prediction had not yet been conducted in ancestries that span African diversity, we calculated polygenic risk scores (PRSs) in simulations across Africa and in empirical data from South Africa, Uganda, and the...

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Identifiers

PMID: 36873096
DOI: 10.1016/j.xhgg.2023.100184
PMCID: PMC9982687

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