Development and Validation of Polygenic Risk Scores for Blood Pressure Traits in Continental African Populations.

doi:10.1161/CIRCGEN.124.005048

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Article

Development and Validation of Polygenic Risk Scores for Blood Pressure Traits in Continental African Populations.

Circulation. Genomic and precision medicine - 1 Jun 2025

Onyenobi Ebuka, Zhong Michael, Soremekun Opeyemi, Kamiza Abram, Boua Romuald, Chikowore Tinashe, Fatumo Segun, Choudhury Ananyo, Hazelhurst Scott, Adebamowo Clement, Ramsay Michèle, Tayo Bamidele, Albrecht Jennifer S, O'Connor Timothy D, Zhang Yuji, Mitchell Braxton D, Adebamowo Sally N

Abstract excerpt

BACKGROUND: Most polygenic risk scores (PRS) have been developed in European populations, frequently leading to limited transferability across diverse ancestry populations. This study aimed to develop and evaluate PRS for blood pressure (BP) traits in continental African populations and investigate how African genetic diversity influences PRS performance. METHODS: We generated PRS for systolic BP, diastolic BP,...

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Topics

Humans
Blood Pressure
Multifactorial Inheritance
Black People
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Hypertension

Male

Middle Aged

Adult

Risk Factors

Genetic Predisposition to Disease

Polymorphism, Single Nucleotide

Genetic Risk Score

Source

Open in PubMed Open full text

Identifiers

PMID: 40421529
DOI: 10.1161/CIRCGEN.124.005048
PMCID: PMC12173169

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