Article
Polygenic risk scores for disease risk prediction in Africa: current challenges and future directions.
Genome medicine - 30 Oct 2023
Fatumo Segun, Sathan Dassen, Samtal Chaimae, Isewon Itunuoluwa, Tamuhla Tsaone, Soremekun Chisom, Jafali James, Panji Sumir, Tiffin Nicki, Fakim Yasmina Jaufeerally
Abstract excerpt
Early identification of genetic risk factors for complex diseases can enable timely interventions and prevent serious outcomes, including mortality. While the genetics underlying many Mendelian diseases have been elucidated, it is harder to predict risk for complex diseases arising from the combined effects of many genetic variants with smaller individual effects on disease aetiology. Polygenic risk scores (PRS),...
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