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Article

Enhancing glycosylase base-editor activity by fusion to transactivation modules.

Cell reports - 19 Jul 2022

Dong Xingxiao, Yang Chao, Ma Zhenzhen, Chen Ming, Zhang Xueli, Bi Changhao

Abstract excerpt

Base editors (BEs) are a group of genetic tools with potential in both scientific and medical research. Recently, a glycosylase BE (GBE), which converts C to G, has been constructed. However, the editing efficiency and targeting scope remains to be further exploited. Here, we renovate the GBE by first fusing it to various transactivation modules including Vp64, leading to a higher conversion of C to G relative to...

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Identifiers

PMID: 35858572
DOI: 10.1016/j.celrep.2022.111090

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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