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A-to-G/C/T and C-to-T/G/A dual-function base editor for creating multi-nucleotide variants.

Journal of genetics and genomics = Yi chuan xue bao - 1 Dec 2024

Ma Bingxiu, Wu Han, Gou Shixue, Lian Meng, Xia Cong, Yang Kaiming, Jin Long, Liu Junyuan, Wu Yunlin, Shu Yahai, Yan Haizhao, Li Zhanjun, Lai Liangxue, Fan Yong

Abstract excerpt

Multi-nucleotide variants (MNVs) are critical genetic variants associated with various genetic diseases. However, tools for precisely installing MNVs are limited. In this study, we present the development of a dual-base editor, BDBE, by integrating TadA-dual and engineered human N-methylpurine DNA glycosylase (eMPG) into nCas9 (D10A). Our results demonstrate that BDBE effectively converts A-to-G/C/T (referred to...

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CRISPR-Associated Protein 9
CRISPR-Cas Systems
DNA Glycosylases
Gene Editing
Genetic Variation

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PMID: 39490920
DOI: 10.1016/j.jgg.2024.10.001

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