Article

Both A-to-G and C-to-T base editing in human cells with dual base editor (A&C-BEmax)

2020-06-02

Abstract excerpt

<title>Abstract</title> <p>As promising genome editing tools, cytidine (CBEs) and adenosine base editors (ABEs) efficiently catalyze C•G to T•A and A•T to G•C conversions, respectively. However, CBEs or ABEs only generate single type of nucleotide conversions, which limits the sequence diversity of edited site and therapeutic applications at certain circumstances. A dual base editor(A&C-BEmax) has been developed...

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Identifiers and source

Literature Corpus work: 316c03c0-6426-5988-8db2-6ada254d57f4
DOI: 10.21203/rs.3.pex-877/v1

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