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Article

CHIP: a clonal odyssey of the bone marrow niche.

The Journal of clinical investigation - 1 Aug 2024

Schleicher Wolfgang E, Hoag Bridget, De Dominici Marco, DeGregori James, Pietras Eric M

Abstract excerpt

Clonal hematopoiesis of indeterminate potential (CHIP) is characterized by the selective expansion of hematopoietic stem and progenitor cells (HSPCs) carrying somatic mutations. While CHIP is typically asymptomatic, it has garnered substantial attention due to its association with the pathogenesis of multiple disease conditions, including cardiovascular disease (CVD) and hematological malignancies. In this...

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Clonal Hematopoiesis
Acute Myeloid Leukemia Research
Bone Marrow
Hematopoietic Stem Cell Transplantation
Hematopoietic Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Myeloproliferative Neoplasms: Diagnosis and Treatment

Stem Cell Niche

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PMID: 39087468
DOI: 10.1172/JCI180068
PMCID: PMC11290965

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