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The kinase activity of integrin-linked kinase regulates cellular senescence in gastric cancer

1 Jul 2022

Abstract excerpt

The activity of integrin-linked kinase (ILK) in cancerous cells is often oncogenic and associated with malignant properties, such as uncontrolled cell cycle progression and evasion from senescence. However, the role of ILK in cellular senescence in gastric cancer (GC) has not been previously examined. We generated single-cell clones of ILK knock-out using CRISPR-Cas9 in human GC lines with mesenchymal or...

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PMID: 35778385
DOI: 10.1038/s41419-022-05020-3

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