Article
Combining High-Content Imaging and Phenotypic Classification Analysis of Senescence-Associated Beta-Galactosidase Staining to Identify Regulators of Oncogene-Induced Senescence.
Assay and drug development technologies - 1 Sept 2016
Chan Keefe T, Paavolainen Lassi, Hannan Katherine M, George Amee J, Hannan Ross D, Simpson Kaylene J, Horvath Peter, Pearson Richard B
Abstract excerpt
Hyperactivation of the PI3K/AKT/mTORC1 signaling pathway is a hallmark of the majority of sporadic human cancers. Paradoxically, chronic activation of this pathway in nontransformed cells promotes senescence, which acts as a significant barrier to malignant progression. Understanding how this oncogene-induced senescence is maintained in nontransformed cells and conversely how it is subverted in cancer cells will...
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