Article
KDM4C-mediated senescence defense is a targetable vulnerability in gastric cancer harboring TP53 mutations.
Clinical epigenetics - 17 Oct 2023
Wang Kaiqing, Gong Zhicheng, Chen Yanyan, Zhang Meimei, Wang Suzeng, Yao Surui, Liu Zhihui, Huang Zhaohui, Fei Bojian
Abstract excerpt
BACKGROUND: Gastric cancer patients harboring a TP53 mutation exhibit a more aggressive and chemoresistant phenotype. Unfortunately, efforts to identify the vulnerabilities to overcome these aggressive malignancies have made minimal progress in recent years. Therefore, there is an urgent need to explore the novel therapeutic strategies for this subclass. Histone methylation modulators are critical epigenetic...
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