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Article

SIK2 represses AKT/GSK3β/β-catenin signaling and suppresses gastric cancer by inhibiting autophagic degradation of protein phosphatases.

Molecular oncology - 1 Jan 2021

Dai Xiao-Man, Zhang Yan-Hui, Lin Xiao-Han, Huang Xiao-Xing, Zhang Yi, Xue Chao-Rong, Chen Wan-Nan, Ye Jian-Xin, Lin Xin-Jian, Lin Xu

Abstract excerpt

Salt-inducible kinase 2 (SIK2) is an important regulator in various intracellular signaling pathways related to apoptosis, tumorigenesis and metastasis. However, the involvement of SIK2 in gastric tumorigenesis and the functional linkage with gastric cancer (GC) progression remain to be defined. Here, we report that SIK2 was significantly downregulated in human GC tissues, and reduced SIK2 expression was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 33128264
DOI: 10.1002/1878-0261.12838
PMCID: PMC7782074

Genes

SIK2
GC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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