Article

Active growth signalling promotes cancer cell sensitivity to the CDK7 inhibitor ICEC0942

2021-09-10

Abstract excerpt

CDK7 has a central role in promoting cellular proliferation, through the activation of the mitotic CDKs, and by driving global gene expression, through targeting RNA polymerase II. Several recently developed CDK7 inhibitors (CDK7i) have been shown to be non-toxic and to limit tumour growth for a number of cancer cell types and are now in Phase I/II clinical trials. However, the mechanisms underlying the sensitivit...

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Identifiers and source

Literature Corpus work: 3e12f663-e148-542f-bead-ee378624824f
DOI: 10.1101/2021.09.10.459733

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