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<i>FoxM1</i> is up‐regulated in gastric cancer and its inhibition leads to cellular senescence, partially dependent on <i>p</i><i>27</i><sup><i>kip</i>1</sup>

29 Jan 2009

Abstract excerpt

The FoxM1 transcription factor, a master regulator of mitotic gene expression, promotes the pathogenesis of several malignancies. However, little is known about its expression and function in gastric cancer. In the present study we determined whether FoxM1 is over-expressed in gastric cancer, and whether it is required to maintain an immortal phenotype of gastric cancer cells. The over-expression of FoxM1 was...

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PMID: 19235838
DOI: 10.1002/path.2530

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