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Article

RHOA drivers take alternate routes in gastric cancer.

Science signaling - 19 Dec 2023

Benton Dorothy, Chernoff Jonathan

Abstract excerpt

Oncogenic small guanosine triphosphatases (GTPases) are often characterized by a limited set of activating mutations that affect their intrinsic biochemical function, but RHOA-which is frequently mutated in gastric cancer-appears not to have read the instruction manual. Having previously characterized the Y42C RHOA mutation in gastric cancer, in this issue of Science Signaling, Schaefer et al. take on the...

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Identifiers

PMID: 38113334
DOI: 10.1126/scisignal.adk9171

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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