The role of integrin-linked kinase (ILK) in cancer progression.

doi:10.1023/a:1023777013659

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Article

The role of integrin-linked kinase (ILK) in cancer progression.

Cancer metastasis reviews - 1 Dec 2003

Persad Sujata, Dedhar Shoukat

Abstract excerpt

Integrin-linked kinase (ILK) is an intracellular protein, which interacts with the cytoplasmic domains of integrin beta and beta3 subunits. ILK is a 59 kDa protein containing a phosphoinositide phospholipid-binding domain flanked by an N-terminal ankyrin repeat domain and a C-terminal serine/threonine protein kinase domain. Genetic and biochemical evidence have established an essential role of ILK in connecting...

Topics

Actins
Amino Acid Sequence
Cell Cycle
Cell Division
Cell Survival
Cell Transformation, Neoplastic
Cytoplasm
Disease Progression
Enzyme Activation
Enzyme Inhibitors
Glycogen Synthase Kinase 3
Humans
Integrins
Models, Biological
Molecular Sequence Data
Neoplasm Invasiveness
Neoplasm Metastasis
Neoplasms

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Open in PubMed

Identifiers

PMID: 12884912
DOI: 10.1023/a:1023777013659

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