Article
The role of integrin-linked kinase (ILK) in cancer progression.
Cancer metastasis reviews - 1 Dec 2003
Persad Sujata, Dedhar Shoukat
Abstract excerpt
Integrin-linked kinase (ILK) is an intracellular protein, which interacts with the cytoplasmic domains of integrin beta and beta3 subunits. ILK is a 59 kDa protein containing a phosphoinositide phospholipid-binding domain flanked by an N-terminal ankyrin repeat domain and a C-terminal serine/threonine protein kinase domain. Genetic and biochemical evidence have established an essential role of ILK in connecting...
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