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On Genetic Correlation Estimation With Summary Statistics From Genome-Wide Association Studies

23 Mar 2021

Abstract excerpt

Cross-trait polygenic risk score (PRS) method has gained popularity for assessing genetic correlation of complex traits using summary statistics from biobank-scale genome-wide association studies (GWAS). However, empirical evidence has shown a common bias phenomenon that highly significant cross-trait PRS can only account for a very small amount of genetic variance (R2 can be <1%) in independent testing GWAS. The...

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PMID: 35757777
DOI: 10.1080/01621459.2021.1906684

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