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Article

Statistical power to detect genetic (co)variance of complex traits using SNP data in unrelated samples.

PLoS genetics - 1 Apr 2014

Visscher Peter M, Hemani Gibran, Vinkhuyzen Anna A E, Chen Guo-Bo, Lee Sang Hong, Wray Naomi R, Goddard Michael E, Yang Jian

Abstract excerpt

We have recently developed analysis methods (GREML) to estimate the genetic variance of a complex trait/disease and the genetic correlation between two complex traits/diseases using genome-wide single nucleotide polymorphism (SNP) data in unrelated individuals. Here we use analytical derivations and simulations to quantify the sampling variance of the estimate of the proportion of phenotypic variance captured by...

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PMID: 24721987
DOI: 10.1371/journal.pgen.1004269
PMCID: PMC3983037

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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