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Human induced pluripotent stem cells generated from a 45-years-old male donor of type 2 diabetes mellitus with APOE-epsilon3/epsilon3 alleles.

Stem cell research - 1 Aug 2022

Cao Shuxing, Guo Ruiyun, Zhang Jinyu, Liu Xin, Zhou Zijing, Song Yongzhou, Ma Jun

Abstract excerpt

Apolipoprotein E (APOE) gene encodes three protein isoforms (APOEε-22/ε-33/ε-44), which governs the transportation and metabolism of lipoproteins differently. While abnormalities in lipid and lipoprotein metabolism have been identified as risk factors for type 2 diabetes mellitus (T2DM). APOE gene polymorphisms might be correlated with increased risk of T2DM. Therefore, we presented an iPSC line harboring an...

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PMID: 35717858
DOI: 10.1016/j.scr.2022.102840

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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