Article
Blood-derived integration-free induced pluripotent stem cells (iPSCs) from one 53-years-old male donor with APOE-ε4/ε4 genotype.
Stem cell research - 1 Jul 2021
Ma Xiaowei, Ma Jun, Guo Ruiyun, Du Juan, Feng Baofeng, Liu Xin, Du Xiaofeng, Ma Zhenhuan, Cui Huixian
Abstract excerpt
Apolipoprotein E ε4 allele (APOE4) is a minor allele of the APOE gene associated with a higher risk for Alzheimer's Disease (AD) and Vascular Dementia (VD). While lipid deposition and chronic inflammation in glia are the commonalities between atherosclerosis, VD, and AD. Hence, we presented an iPSC line of an AD male donor suffering from Cerebrovascular Atherosclerosis with APOE-ε4/ε4 alleles background....
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