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Generation of induced pluripotent stem cell line (IPTi001-A) from a 62-year old sporadic Alzheimer's disease patient with APOE3 (ε3/ε3) genotype.

Stem cell research - 1 Dec 2019

Zhang Lin, Xu Mei, Liu Gang, Wu Rongrong, Meng Shulin, Xiahou Kang, Jiang Ning, Zhang Yongxiang, Zhou Wenxia

Abstract excerpt

A 62-year old sporadic Alzheimer's disease (sAD) male patient with APOE3 (ε3/ε3) genotype donated his peripheral blood mononuclear cells (PBMCs). The induced pluripotent stem cell (iPSC) line was established by episomal vector system with the four factors OCT4, SOX2, C-MYC and KLF4. EB differentiation in vitro showed that iPSC line had a potential to differentiate into three germ layers. More than 90% cells...

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Identifiers

PMID: 31689594
DOI: 10.1016/j.scr.2019.101589

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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