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Induced pluripotent stem cells derived from one 70-years-old male donor with the APOE-ε4/ε4 alleles.

Stem cell research - 1 May 2021

Wang Jin, Liu Xin, Du Xiaofeng, Ma Zhenhuan, Liu Boxin, Guo Ruiyun, Feng Baofeng, Ma Jun, Cui Huixian

Abstract excerpt

Apolipoprotein E (ApoE) is a lipid-binding protein with ε2, ε3, and ε4 allelic variants in human. The ε4 isoform (ApoE4) is the strongest genetic risk factor for the late-onset form of Alzheimer's disease (AD), and is also associated with multiple neurological disorders, multiple sclerosis, and cerebrovascular disease. Here, induced pluripotent stem cells were derived from the peripheral blood mononuclear cells...

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Identifiers

PMID: 34088020
DOI: 10.1016/j.scr.2021.102395

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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