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Generation of a human induced pluripotent stem cell line (HEBHMUi019-A) from a 67-year-old male Alzheimer's patient with APOE-ε4/ε4 genotype.

Stem cell research - 1 Sept 2026

Ma Jiajia, Hua Zilin, Zhao Boyao, Xu Jingrong, Bao Kexin, Guo Ruiyun

Abstract excerpt

Apolipoprotein E (apoE), encoded by the polymorphic APOE gene, plays a key role in lipid transport and metabolism. The three major APOE alleles are ε2, ε3, and ε4, with ε4 being the strongest genetic risk factor for late-onset Alzheimer's disease. We generated human induced pluripotent stem cells from peripheral blood mononuclear cells of a 67-year-old male patient with Alzheimer's disease carrying the APOE ε4/ε4...

Read the complete abstract on PubMed

Topics

Humans
Male
Alzheimer Disease
Induced Pluripotent Stem Cells
Aged
Apolipoprotein E4

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genotype

Cell Differentiation

Cell Line

Source

Identifiers

PMID: 42603521
DOI: 10.1016/j.scr.2026.104082

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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