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Generation of induced pluripotent stem cell line (IPTi002-A) from an 87-year old sporadic Alzheimer's disease patient with APOE3 (ε3/ε3) genotype.

Stem cell research - 1 May 2021

Zhang Lin, Ren Qiao, Liu Xiaohui, Liu Gang, Meng Shulin, Xiahou Kang, Zhang Yongxiang, Jiang Ning, Zhou Wenxia

Abstract excerpt

Here, we described the generation of human induced pluripotent stem cells (iPSC) from peripheral blood mononuclear cells (PBMCs) of a 87-year-old female patient with sporadic Alzheimer's disease (sAD) having APOE3 (ε3/ε3) genotype. iPSC line were generated from PBMCs with four factors of OCT4, SOX2, c-MYC and KLF4 using episomal system. The pluripotency of the iPSC line was assessed by embryoid body (EB)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33799279
DOI: 10.1016/j.scr.2021.102282

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