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Article

An integration-free induced pluripotent stem cell line from a 42-year-old female donor with the APOE-ε2/ε2 allele.

Stem cell research - 1 Oct 2024

Wang Lianying, Guo Ruiyun, Zhang Xiaohan, Zhou Zijing, Yao Akogo Herman, Fu Zewei, Song Yongzhou, Li Ming, Ma Jun

Abstract excerpt

The APOE 4 allele remains the primary genetic risk factor for sporadic Alzheimer's disease, whereas the APOE 2 allele emerges as a protective factor. Therapeutic approaches in murine models with human APOE alleles, such as modulating APOE levels and converting isoforms, show efficacy. However, there is a lack of in vitro APOE2-mutant human neuronal models. Hence, in this study, we generated human induced...

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PMID: 39094506
DOI: 10.1016/j.scr.2024.103506

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