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Article

APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes.

Human molecular genetics - 15 Jul 2017

Zhao Jing, Davis Mary D, Martens Yuka A, Shinohara Mitsuru, Graff-Radford Neill R, Younkin Steven G, Wszolek Zbigniew K, Kanekiyo Takahisa, Bu Guojun

Abstract excerpt

The ε4 allele of the APOE gene encoding apolipoprotein E (apoE) is a strong genetic risk factor for aging-related cognitive decline as well as late-onset Alzheimer's disease (AD) compared to the common ε3 allele. In the central nervous system, apoE is produced primarily by astrocytes and functions in transporting lipids including cholesterol to support neuronal homeostasis and synaptic integrity. Although mouse...

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Identifiers

PMID: 28444230
DOI: 10.1093/hmg/ddx155
PMCID: PMC5886091

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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