Article
Generation of a set of isogenic iPSC lines carrying all APOE genetic variants (Ɛ2/Ɛ3/Ɛ4) and knock-out for the study of APOE biology in health and disease.
Stem cell research - 1 Apr 2021
Schmid Benjamin, Holst Bjørn, Clausen Christian, Bahnassawy Lamiaa, Reinhardt Peter, Bakker Margot H M, Díaz-Guerra Eva, Vicario Carlos, Martino-Adami Pamela V, Thoenes Michaela, Ramirez Alfredo, Fliessbach Klaus, Grezella Clara, Brüstle Oliver, Peitz Michael, Ebneth Andreas, Cabrera-Socorro Alfredo
Abstract excerpt
APOE genotype is the strongest genetic risk factor for Alzheimer's Disease (AD). The low degree of homology between mouse and human APOE is a concerning issue in preclinical models currently used to study the role of this gene in AD pathophysiology. A key objective of ADAPTED (Alzheimer's Disease Apolipoprotein Pathology for Treatment Elucidation and Development) project was to generate in vitro models that...
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