Article
Genome-wide association study of Alzheimer's disease.
Translational psychiatry - 15 May 2012
Kamboh M I, Demirci F Y, Wang X, Minster R L, Carrasquillo M M, Pankratz V S, Younkin S G, Saykin A J, Jun G, Baldwin C, Logue M W, Buros J, Farrer L, Pericak-Vance M A, Haines J L, Sweet R A, Ganguli M, Feingold E, Dekosky S T, Lopez O L, Barmada M M
Abstract excerpt
In addition to apolipoprotein E (APOE), recent large genome-wide association studies (GWASs) have identified nine other genes/loci (CR1, BIN1, CLU, PICALM, MS4A4/MS4A6E, CD2AP, CD33, EPHA1 and ABCA7) for late-onset Alzheimer's disease (LOAD). However, the genetic effect attributable to known loci is about 50%, indicating that additional risk genes for LOAD remain to be identified. In this study, we have used a...
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