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Article

Association of Variants in PINX1 and TREM2 With Late-Onset Alzheimer Disease

7 May 2019

Abstract excerpt

IMPORTANCE: Genetic causes of late-onset Alzheimer disease (LOAD) are not completely explained by known genetic loci. Whole-exome and whole-genome sequencing can improve the understanding of the causes of LOAD and provide initial steps required to identify potential therapeutic targets. OBJECTIVE: To identify the genetic loci for LOAD across different ethnic groups. DESIGN, SETTING, AND PARTICIPANTS: This...

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PMID: 31058951
DOI: 10.1001/jamaneurol.2019.1066

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