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Article

Genetic variants influencing human aging from late-onset Alzheimer's disease (LOAD) genome-wide association studies (GWAS).

Neurobiology of aging - 1 Aug 2012

Shi Hui, Belbin Olivia, Medway Christopher, Brown Kristelle, Kalsheker Noor, Carrasquillo Minerva, Proitsi Petroula, Powell John, Lovestone Simon, Goate Alison, Younkin Steven, Passmore Peter, Morgan Kevin

Abstract excerpt

Genetics plays a crucial role in human aging with up to 30% of those living to the mid-80s being determined by genetic variation. Survival to older ages likely entails an even greater genetic contribution. There is increasing evidence that genes implicated in age-related diseases, such as cancer and neuronal disease, play a role in affecting human life span. We have selected the 10 most promising late-onset...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22445811
DOI: 10.1016/j.neurobiolaging.2012.02.014
PMCID: PMC4120742

Genes

APOE
ABCA7
BIN1
CLU
EPHA1
PICALM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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