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Article

Late-Onset Alzheimer’s Disease Genes and the Potentially Implicated Pathways

21 Mar 2014

Abstract excerpt

Late-onset Alzheimer’s disease (LOAD) is a devastating neurodegenerative disease with no effective treatment or cure. In addition to APOE , recent large genome-wide association studies have identified variation in over 20 loci that contribute to disease risk: CR1, BIN1, INPP5D, MEF2C, TREM2, CD2AP, HLA - DRB1/HLA - DRB5, EPHA1, NME8, ZCWPW1, CLU, PTK2B, PICALM, SORL1, CELF1, MS4A4/MS4A6E, SLC24A4/RIN3,FERMT2,...

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PMID: 24829845
DOI: 10.1007/s40142-014-0034-x

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