Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genotype-phenotype correlation of T-cell subtypes reveals senescent and cytotoxic genes in Alzheimer's disease.

Human molecular genetics - 29 Sept 2022

Dressman Dallin, Buttrick Thomas, Cimpean Maria, Bennett David, Menon Vilas, Bradshaw Elizabeth M, Vardarajan Badri, Elyaman Wassim

Abstract excerpt

Recent studies identifying expression quantitative trait loci (eQTLs) in immune cells have uncovered important links between disease risk alleles and gene expression trends in monocytes, T cells and other cell types. However, these studies are generally done with young, healthy subjects, limiting the utility of their findings for age-related conditions such as Alzheimer's disease (AD). We have performed RNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Genetic Association Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Neurodegenerative Diseases

Share to Polymorphism, Single Nucleotide

Share to T-Lymphocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 35640154
DOI: 10.1093/hmg/ddac126
PMCID: PMC9523563

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genotype-phenotype correlation of T-cell subtypes reveals senescent and cytotoxic genes in Alzheimer's disease.PMID 35640154Read ↗

Genotype-Phenotype Correlation of T Cell Subtypes Reveals Senescent and Cytotoxic Genes in Alzheimer’s DiseaseSemantic proximity Read ↗

Aging shapes the population-mean and ‐dispersion of gene expression in human brainsSemantic proximity Read ↗

Polygenic Risk Associated with Alzheimer’s Disease and Other Traits Influences Genes Involved in T Cell Signaling and ActivationSemantic proximity Read ↗

Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes.Semantic proximity Read ↗

Cell-type-specific expression quantitative trait loci associated with Alzheimer disease in blood and brain tissue.Semantic proximity Read ↗

Polygenic risk associated with Alzheimer's disease and other traits influences genes involved in T cell signaling and activation.Semantic proximity Read ↗

Cell subtype-specific effects of genetic variation in the Alzheimer's disease brain.Semantic proximity Read ↗

Sexual-dimorphism in human immune system agingSemantic proximity Read ↗

The Peripheral Immune-Sleep- Cognition Axis Across Diagnostic Stages of Alzheimer’s DiseaseSemantic proximity Read ↗

Regional genetic correlations highlight relationships between neurodegenerative disease loci and the immune system.Semantic proximity Read ↗

Cell-type Specific Expression Quantitative Trait Loci Associated with Alzheimer Disease in Blood and Brain TissueSemantic proximity Read ↗

Peripheral immune profiles in individuals at genetic risk for amyotrophic lateral sclerosis and Alzheimer’s diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.